Recent advances in the chemistry and biology of new generation taxoids.
about
A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy.Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel.Drug discovery targeting cell division proteins, microtubules and FtsZ.Survivin is not induced by novel taxanes.Design, Synthesis and Application of Fluorine-Labeled Taxoids as (19)F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems.Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugatesPoly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery.Taxane anticancer agents: a patent perspective.Asymmetric synthesis of anti-β-amino-α-hydroxy esters via dynamic kinetic resolution of β-amino-α-keto esters.New microtubule-inhibiting anticancer agents.Practical synthesis of fluorine-containing α- and β-amino acids: recipes from Kiev, Ukraine.Diterpenoids of terrestrial origin.Molecular simulations of drug-receptor complexes in anticancer research.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies.Evaluation of the tissue distribution, excretion, and cytochrome P450 induction studies of a potential antitumor agent, TM-2, in animals using LC-MS/MS.New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells.Advances in the chemistry of β-lactam and its medicinal applications.Characterization of in vitro metabolites of TM-2, a potential antitumor drug, in rat, dog and human liver microsomes using liquid chromatography/tandem mass spectrometry.Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
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P2860
Recent advances in the chemistry and biology of new generation taxoids.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Recent advances in the chemistry and biology of new generation taxoids.
@en
Recent advances in the chemistry and biology of new generation taxoids.
@nl
type
label
Recent advances in the chemistry and biology of new generation taxoids.
@en
Recent advances in the chemistry and biology of new generation taxoids.
@nl
prefLabel
Recent advances in the chemistry and biology of new generation taxoids.
@en
Recent advances in the chemistry and biology of new generation taxoids.
@nl
P2860
P356
P1476
Recent advances in the chemistry and biology of new generation taxoids.
@en
P2093
Iwao Ojima
Manisha Das
P2860
P304
P356
10.1021/NP8006556
P577
2009-03-01T00:00:00Z