HIPK2 modulates p53 activity towards pro-apoptotic transcription. - Wikidata - awgldk - TriplyDB

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

http://www.wikidata.org/entity/Q37402028

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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen p53 Acetylation: Regulation and Consequences Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax Interplay between Mdm2 and HIPK2 in the DNA damage response.HIV infection upregulates caveolin 1 expression to restrict virus production.Zinc bells rang in Jerusalem!High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes Zfra is a small wizard in the mitochondrial apoptosis HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System Updates on HIPK2: a resourceful oncosuppressor for clearing cancer Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.Estrogen receptors β1 and β2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3.HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy Gentian violet induces wtp53 transactivation in cancer cells Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors.G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice.HIPK2 modification code for cell death and survival.The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells.Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro.Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.Different functions of HIPK2 and CtBP2 in traumatic brain injury.p300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function.Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis

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P2860

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

http://www.wikidata.org/entity/Q37402028

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 14 October 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

@en

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

@nl

type

label

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

@en

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

@nl

prefLabel

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

@en

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

@nl

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Molecular Cancer

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HIPK2 modulates p53 activity towards pro-apoptotic transcription.

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Ada Sacchi

http://www.w3.org/2001/XMLSchema#string

David Givol

http://www.w3.org/2001/XMLSchema#string

Gabriella D'Orazi

http://www.w3.org/2001/XMLSchema#string

Gideon Rechavi

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Lavinia Nardinocchi

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Rosa Puca

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P2860

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

Deacetylation of p53 modulates its effect on cell growth and apoptosis

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85

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scholarly article

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10.1186/1476-4598-8-85

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8

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2009-10-14T00:00:00Z

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38010523

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1030991805

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19828042

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apoptotic process

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2768676

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