Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI.
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Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewCardiac troponin mutations and restrictive cardiomyopathyCell biology of sarcomeric protein engineering: disease modeling and therapeutic potentialClinical and Mechanistic Insights Into the Genetics of CardiomyopathyTo investigate protein evolution by detecting suppressed epitope structuresCalcium-regulated conformational change in the C-terminal end segment of troponin I and its binding to tropomyosinTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.New approaches in small animal echocardiography: imaging the sounds of silence.Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy.Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathyLeft ventricular and aortic dysfunction in cystic fibrosis mice.Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutationsSenescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction.Measurement of calcium dissociation rates from troponin C in rigor skeletal myofibrils.N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition.Application of echocardiography on transgenic mice with cardiomyopathies.Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Cardiac arrhythmia and heart failure: From bench to bedsideInsights into restrictive cardiomyopathy from clinical and animal studies.Ventricular remodeling and function: insights using murine echocardiography.Echocardiography in Mice.Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Restrictive Cardiomyopathy Caused by Troponin Mutations: Application of Disease Animal Models in Translational StudiesProtein kinase C phosphomimetics alter thin filament Ca2+ binding properties.Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations.Pediatric restrictive cardiomyopathy due to a heterozygous mutation of the TNNI3 gene.Green tea extract catechin improves internal cardiac muscle relaxation in RCM mice.Protective effects of taurine against oxidative stress in the heart of MsrA knockout mice.Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling.Role of Whole-exome Sequencing in Phenotype Classification and Clinical Treatment of Pediatric Restrictive Cardiomyopathy.
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Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@en
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@nl
type
label
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@en
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@nl
prefLabel
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@en
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@nl
P2093
P2860
P1476
Impaired relaxation is the mai ...... tation, R193H, in cardiac TnI.
@en
P2093
Han-Zhong Feng
Jian-Ping Jin
Jianfeng Du
M M Hossain
Nariman Gobara
Pierre-Yves Jean-Charles
Xu-Pei Huang
P2860
P304
P356
10.1152/AJPHEART.91506.2007
P577
2008-04-11T00:00:00Z