Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure.
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Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1Trp-26 imparts functional versatility to human alpha-defensin HNP1The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistanceStrain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenesPeptide fragments of a beta-defensin derivative with potent bactericidal activity.Hydrophobic determinants of α-defensin bactericidal activity.Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS.Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa.Paneth cell α-defensins in enteric innate immunityGuanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranesEngineering persister-specific antibiotics with synergistic antimicrobial functionsEffect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins.Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptidesArginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior.Critical determinants of human α-defensin 5 activity against non-enveloped viruses.Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering.α-Defensins in human innate immunity.Probing the disparate effects of arginine and lysine residues on antimicrobial peptide/bilayer association.Linear bactenecin analogs with cell selectivity and anti-endotoxic activity.Guardians of the Gut: Enteric Defensins.Targeting and inactivation of bacterial toxins by human defensins.Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.Effect of substituting arginine and lysine with alanine on antimicrobial activity and the mechanism of action of a cationic dodecapeptide (CL(14-25)), a partial sequence of cyanate lyase from rice.A Simplified Derivative of Human Defensin 5 with Potent Efficiency against Multidrug-resistant Acinetobacter baumannii.Characterization and production of multifunctional cationic peptides derived from rice proteins.An engineered arginine-rich α-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in miceThe potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation
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P2860
Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Electropositive charge in alph ...... the peptide primary structure.
@en
Electropositive charge in alph ...... the peptide primary structure.
@nl
type
label
Electropositive charge in alph ...... the peptide primary structure.
@en
Electropositive charge in alph ...... the peptide primary structure.
@nl
prefLabel
Electropositive charge in alph ...... the peptide primary structure.
@en
Electropositive charge in alph ...... the peptide primary structure.
@nl
P2093
P2860
P356
P1476
Electropositive charge in alph ...... the peptide primary structure.
@en
P2093
André J Ouellette
Colby S Weeks
Melanie J Cocco
R Alan Llenado
P2860
P304
P356
10.1128/IAI.00695-09
P407
P577
2009-09-08T00:00:00Z