Structure-function relationship of Vpr: biological implications.
about
Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pHFormation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrestHIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag.Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding.Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell deathHIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localizationA protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis.HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome.Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions.HIV-1 Vpr increases Env expression by preventing Env from endoplasmic reticulum-associated protein degradation (ERAD).HIV1-viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies.In Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design.Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.
P2860
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P2860
Structure-function relationship of Vpr: biological implications.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Structure-function relationship of Vpr: biological implications.
@en
Structure-function relationship of Vpr: biological implications.
@nl
type
label
Structure-function relationship of Vpr: biological implications.
@en
Structure-function relationship of Vpr: biological implications.
@nl
prefLabel
Structure-function relationship of Vpr: biological implications.
@en
Structure-function relationship of Vpr: biological implications.
@nl
P2093
P1433
P1476
Structure-function relationship of Vpr: biological implications.
@en
P2093
Bernard P Roques
Nelly Morellet
Serge Bouaziz
P304
P356
10.2174/157016209787581490
P577
2009-03-01T00:00:00Z