Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II.
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Reactive Oxygen Species in the Paraventricular Nucleus of the Hypothalamus Alter Sympathetic Activity During Metabolic SyndromeBiochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular systemRegulation of hypothalamic renin-angiotensin system and oxidative stress by aldosteroneRegulation of pancreatic cancer growth by superoxideNADPH oxidases in vascular pathology.New insights on NOX enzymes in the central nervous system.Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humansSilencing nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis.Reactive oxygen species, NADPH oxidases, and hypertension.Central interactions of aldosterone and angiotensin II in aldosterone- and angiotensin II-induced hypertension.Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4Angiotensin II and angiotensin-1-7 redox signaling in the central nervous system.Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ.NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies.Genetic knockdown of estrogen receptor-alpha in the subfornical organ augments ANG II-induced hypertension in female mice.Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicityRole of oxidative stress in disease progression in Stage B, a pre-cursor of heart failure.Central angiotensin II has catabolic action at white and brown adipose tissueAngiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain.The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension.PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice.NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress.The NOX toolbox: validating the role of NADPH oxidases in physiology and disease.Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signalingCross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleusCIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22 (phox) N-Terminus: An Elusive Target.NADPH oxidase 4 regulates cardiomyocyte differentiation via redox activation of c-Jun protein and the cis-regulation of GATA-4 gene transcriptionAdvanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling.Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons.Nox2 and Nox4 influence neonatal c-kit(+) cardiac precursor cell status and differentiation.NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organEGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC.Redox signaling in cardiovascular health and disease.Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ.Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension.Angiotensin II-derived reactive oxygen species underpinning the processing of the cardiovascular reflexes in the medulla oblongata.The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension
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Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@en
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@nl
type
label
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@en
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@nl
prefLabel
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@en
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@nl
P2093
P2860
P1433
P1476
Genetic silencing of Nox2 and ...... fects of brain angiotensin II.
@en
P2093
Jeffrey R Peterson
John A Stupinski
Mallikarjuna R Guruju
Melissa A Burmeister
Ram V Sharma
Robin L Davisson
P2860
P304
P356
10.1161/HYPERTENSIONAHA.109.140087
P407
P577
2009-10-05T00:00:00Z