High fidelity and lesion bypass capability of human DNA polymerase delta
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The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conservedAn in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophyDNA polymerase ε and its roles in genome stabilityStructural insights into eukaryotic DNA replicationDNA polymerase delta in DNA replication and genome maintenanceNew insights into the generation and role of de novo mutations in health and diseaseExonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replicationThe Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δEukaryotic genome instability in light of asymmetric DNA replicationThe high fidelity and unique error signature of human DNA polymerase epsilonDNA replication error-induced extinction of diploid yeastThe struggle to find reliable results in exome sequencing data: filtering out Mendelian errors.Human cancers express mutator phenotypes: origin, consequences and targeting.Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantSphingosine, a modulator of human translesion DNA polymerase activityActive site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.Recombination drives vertebrate genome contraction.Mutator phenotypes due to DNA replication infidelity.The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparumThe POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.Balancing eukaryotic replication asymmetry with replication fidelity.Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability.Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction.Base excision repair in physiology and pathology of the central nervous systemA substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site.Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis.Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-))DNA polymerases and cancer.DNA damage tolerance and a web of connections with DNA repair at Yale.Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1.Nucleotide selection by the Y-family DNA polymerase Dpo4 involves template translocation and misalignment.In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.Catalytic and non-catalytic roles of DNA polymerase κ in the protection of human cells against genotoxic stresses.POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologiesTranslesion DNA polymerases in eukaryotes: what makes them tick?Replication-associated mutational asymmetry in the human genome.Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells.Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage.Characterization of human translesion DNA synthesis across a UV-induced DNA lesion
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High fidelity and lesion bypass capability of human DNA polymerase delta
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
High fidelity and lesion bypass capability of human DNA polymerase delta
@en
High fidelity and lesion bypass capability of human DNA polymerase delta.
@nl
type
label
High fidelity and lesion bypass capability of human DNA polymerase delta
@en
High fidelity and lesion bypass capability of human DNA polymerase delta.
@nl
prefLabel
High fidelity and lesion bypass capability of human DNA polymerase delta
@en
High fidelity and lesion bypass capability of human DNA polymerase delta.
@nl
P2860
P1433
P1476
High fidelity and lesion bypass capability of human DNA polymerase delta
@en
P2093
Lawrence A Loeb
Michael W Schmitt
P2860
P304
P356
10.1016/J.BIOCHI.2009.06.007
P577
2009-06-18T00:00:00Z