An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.
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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNADNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and BeyondStructure-function studies of DNA polymerase λMUTYH the base excision repair gene family member associated with colorectal cancer polyposisUnique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iotaA fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dGA switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesionsAlkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylationInter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchInvolvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase βInfluence of oxidized purine processing on strand directionality of mismatch repairA new proofreading mechanism for lesion bypass by DNA polymerase-λ.Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.The awakening of an advanced malignant cancer: an insult to the mitochondrial genomeCancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.Base excision repair in physiology and pathology of the central nervous systemDNA polymerase λ inactivation by oxidized abasic sites.Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.Understanding the role of the Q338H MUTYH variant in oxidative damage repairRegulation of DNA glycosylases and their role in limiting disease.DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypassRegulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity.DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.Ubiquitylation of DNA polymerase λ.Base excision repair targets for cancer therapyImpact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.Genetic instability in lymphoblastoid cell lines expressing biallelic and monoallelic variants in the human MUTYH gene.Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families.MutYH mutation carriers have increased breast cancer risk.MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation.ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe.A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells.Unlike catalyzing error-free bypass of 8-oxodGuo, DNA polymerase λ is responsible for a significant part of Fapy·dG-induced G → T mutations in human cells.Translesion Synthesis of 2'-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases.Patterns and mutational signatures of tandem base substitutions causing human inherited disease.Common MUTYH mutations and colorectal cancer risk in multiethnic populations.
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An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@en
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@nl
type
label
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@en
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@nl
prefLabel
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@en
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@nl
P2860
P356
P1476
An 8-oxo-guanine repair pathwa ...... ase and DNA polymerase lambda.
@en
P2093
Ulrich Hübscher
P2860
P304
18201-18206
P356
10.1073/PNAS.0907280106
P407
P577
2009-10-09T00:00:00Z