Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
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Changes in human pluripotent stem cell gene expression after genotoxic stress exposuresThe DNA damage response: the omics era and its impact.TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damagep53: the barrier to cancer stem cell formation.Cell context dependent p53 genome-wide binding patterns and enrichment at repeats.p53 binding to human genome: crowd control navigation in chromatin contextInteractions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activityThe histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cellsThe Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.STB-HO, a novel mica fine particle, inhibits the teratoma-forming ability of human embryonic stem cells after in vivo transplantation.An essential role for UTX in resolution and activation of bivalent promoters.Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cellsBrg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest.Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice.Comparison of the early response of human embryonic stem cells and human induced pluripotent stem cells to ionizing radiation.The effect of non-coding DNA variations on P53 and cMYC competitive inhibition at cis-overlapping motifs.Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer.G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling.Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review).Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivoIdentification of p53-target genes in Danio rerioIdentification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development.LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56.Conservation and Divergence of p53 Oscillation Dynamics across Species.p53 binding sites in normal and cancer cells are characterized by distinct chromatin context.UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome.TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.Reciprocity of Action of Increasing Oct4 and Repressing p53 in Transdifferentiation of Mouse Embryonic Fibroblasts into Cardiac Myocytes.Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells.Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells.X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism.p53-Dependent and -Independent Epithelial Integrity: Beyond miRNAs and Metabolic Fluctuations.JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AMLRevealing a human p53 universe
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Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Genome-wide profiling reveals ...... of human embryonic stem cells
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Genome-wide profiling reveals ...... of human embryonic stem cells.
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type
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Genome-wide profiling reveals ...... of human embryonic stem cells
@en
Genome-wide profiling reveals ...... of human embryonic stem cells.
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prefLabel
Genome-wide profiling reveals ...... of human embryonic stem cells
@en
Genome-wide profiling reveals ...... of human embryonic stem cells.
@nl
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P50
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Genome-wide profiling reveals ...... of human embryonic stem cells
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Austin J Cooney
Kadir C Akdemir
Xueping Xu
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P304
P356
10.1093/NAR/GKT866
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P577
2013-09-27T00:00:00Z