A distinct DNA-methylation boundary in the 5'- upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome.
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Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X SyndromeFragile X syndromeThe promise and perils of HDAC inhibitors in neurodegenerationRole of CTCF protein in regulating FMR1 locus transcriptionTranscription-associated R-loop formation across the human FMR1 CGG-repeat regionPotential therapeutic interventions for fragile X syndromeEpigenetic analysis of HIV-1 proviral genomes from infected individuals: predominance of unmethylated CpG's.FMR1 intron 1 methylation predicts FMRP expression in blood of female carriers of expanded FMR1 alleles.Impact of foreign DNA integration on tumor biology and on evolution via epigenetic alterations.The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissuesAberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island.Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics.Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndromeEpigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy.Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells.RNA-mediated toxicity in neurodegenerative diseasemTOR, a Potential Target to Treat Autism Spectrum Disorder.Methotrexate treatment of FraX fibroblasts results in FMR1 transcription but not in detectable FMR1 protein levels.Epigenetic consequences of foreign DNA insertions: de novo methylation and global alterations of methylation patterns in recipient genomes.Gene regulation and epigenetics in Friedreich's ataxia.Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development.The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases.Human pluripotent stem cell models of Fragile X syndrome.Human pluripotent stem cells in modeling human disorders: the case of fragile X syndrome.Destabilization of the human epigenome: consequences of foreign DNA insertions.Beware of manipulations on the genome: epigenetic destabilization through (foreign) DNA insertions.Comparative (computational) analysis of the DNA methylation status of trinucleotide repeat expansion diseases.Size and methylation mosaicism in males with Fragile X syndrome.Epigenetic Aberration of FMR1 Gene in Infertile Women with Diminished Ovarian Reserve.Intracellular African swine fever virus DNA remains unmethylated in infected Vero cells.The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients.Reevaluation of FMR1 Hypermethylation Timing in Fragile X Syndrome.Epigenetics, fragile X syndrome and transcriptional therapy.
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P2860
A distinct DNA-methylation boundary in the 5'- upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
@en
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
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type
label
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
@en
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
@nl
prefLabel
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
@en
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
@nl
P2093
P2860
P1476
A distinct DNA-methylation bou ...... is lost in fragile X syndrome.
@en
P2093
Anja Naumann
Ellen Fanning
Norbert Hochstein
Stefanie Weber
P2860
P304
P356
10.1016/J.AJHG.2009.09.018
P407
P577
2009-10-22T00:00:00Z