Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. - Wikidata - awgldk - TriplyDB

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

http://www.wikidata.org/entity/Q37418266

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PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism Glucose sensing neurons in the ventromedial hypothalamus Living without insulin: the role of leptin signaling in the hypothalamus Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells Leptin revisited: its mechanism of action and potential for treating diabetes.Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis Leptin signaling.Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway Melanocortin control of energy balance: evidence from rodent models.Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.Central effects of humanin on hepatic triglyceride secretion.Intracerebroventricular injection of metformin induces anorexia in rats.The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog.Central regulation of metabolism by protein tyrosine phosphatases PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia.Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons.Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons.Evidence for central regulation of glucose metabolism.Central insulin and leptin-mediated autonomic control of glucose homeostasis.Sex differences in the effects of androgens acting in the central nervous system on metabolism.Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes.The PI3K signaling pathway mediates the biological effects of leptin.Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production Structure, production and signaling of leptin.Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.Hypothalamic neurones governing glucose homeostasis.Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis.Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.FGF1 - a new weapon to control type 2 diabetes mellitus.Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus.DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance.Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain.

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Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

http://www.wikidata.org/entity/Q37418266

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

@en

Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

@nl

type

label

Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

@en

Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

@nl

prefLabel

Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

@en

Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

@nl

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Phosphatidyl inositol 3-kinase ...... lation of glucose homeostasis.

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Barbara B Kahn

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Frederic Preitner

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Jean J Zhao

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Ji Luo

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Joel K Elmquist

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Makota Fukuda

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Nina Balthasar

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Roberto Coppari

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Yong Xu

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You-Ree Cho

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Annual Deaths Attributable to Obesity in the United States

Prevalence and Trends in Obesity Among US Adults, 1999-2000

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

The melanocortin system and energy balance

The phosphoinositide 3-kinase pathway

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

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4874-4882

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10.1210/EN.2009-0454

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11

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Lewis C. Cantley

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2009-10-09T00:00:00Z

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26885706

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19819947

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