Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
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Crystal structure of native RPE65, the retinoid isomerase of the visual cycleImportance of Membrane Structural Integrity for RPE65 Retinoid Isomerization ActivityStructure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.Identification of key residues determining isomerohydrolase activity of human RPE65Membrane-binding and enzymatic properties of RPE65Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activityPharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital AmaurosisNegative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.Rescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brainInhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease.Key enzymes of the retinoid (visual) cycle in vertebrate retinaTemperature-sensitive retinoid isomerase activity of RPE65 mutants associated with Leber Congenital AmaurosisAn alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species.Identification of the key residues determining the product specificity of isomerohydrolase.Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid MetabolismSubstrate Specificity of Purified Recombinant Chicken β-Carotene 9',10'-Oxygenase (BCO2).Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme.Retinyl ester hydrolases and their roles in vitamin A homeostasis.Copy number variation in Fayoumi and Leghorn chickens analyzed using array comparative genomic hybridization.Preserved visual function in retinal dystrophy due to hypomorphic RPE65 mutations.A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.
P2860
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P2860
Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
@en
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
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type
label
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
@en
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
@nl
prefLabel
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
@en
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
@nl
P2093
P2860
P1433
P1476
Purified RPE65 shows isomerohy ...... with a phospholipid membrane.
@en
P2093
Gennadiy Moiseyev
Jian-Xing Ma
Olga Nikolaeva
Yusuke Takahashi
P2860
P304
P356
10.1111/J.1742-4658.2009.07021.X
P407
P577
2009-04-20T00:00:00Z