Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene. - Wikidata - awgldk - TriplyDB

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

http://www.wikidata.org/entity/Q37422689

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Hypothesis-based weight-of-evidence evaluation and risk assessment for naphthalene carcinogenesis.Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice.ATP and Odor Mixture Activate TRPM5-Expressing Microvillous Cells and Potentially Induce Acetylcholine Release to Enhance Supporting Cell Endocytosis in Mouse Main Olfactory Epithelium.

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Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

http://www.wikidata.org/entity/Q37422689

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 October 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Essential role of the cytochro ...... cosal toxicity of naphthalene.

@en

Essential role of the cytochro ...... cosal toxicity of naphthalene.

@nl

type

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Essential role of the cytochro ...... cosal toxicity of naphthalene.

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Essential role of the cytochro ...... cosal toxicity of naphthalene.

@nl

prefLabel

Essential role of the cytochro ...... cosal toxicity of naphthalene.

@en

Essential role of the cytochro ...... cosal toxicity of naphthalene.

@nl

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Drug Metabolism and Disposition

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Essential role of the cytochro ...... cosal toxicity of naphthalene.

@en

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Fang Xie

http://www.w3.org/2001/XMLSchema#string

Jaime D'Agostino

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Jinping Hu

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Lei Li

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Li Sheng

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Xin Zhou

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Xinxin Ding

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Yan Li

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Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.

The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5

Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.

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Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa

Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

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23-27

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10.1124/DMD.113.054429

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