Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial

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Phelan-McDermid syndrome data network: Integrating patient reported outcomes with clinical notes and curated genetic reports.Identification of 22q13 genes most likely to contribute to Phelan McDermid syndrome.Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.

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Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial

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bilimsel makale

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scientific article published on 31 August 2016

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vedecký článok

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Is there an effect of intranas ...... lind, placebo-controlled trial

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Is there an effect of intranas ...... ind, placebo-controlled trial.

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Is there an effect of intranas ...... lind, placebo-controlled trial

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Is there an effect of intranas ...... lind, placebo-controlled trial

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Boudien C T Flapper

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Conny M A van Ravenswaaij-Arts

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Edwin R van den Heuvel

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Gianni Bocca

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Jan H Dillingh

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Renée J Zwanenburg

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Selma A J Ruiter

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P2860

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses

The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)

Molecular characterisation of the 22q13 deletion syndrome supports the role of haploinsufficiency of SHANK3/PROSAP2 in the major neurological symptoms

Autism spectrum disorder in Phelan-McDermid syndrome: initial characterization and genotype-phenotype correlations

Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice

P2888

ejhg.2016.109

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1696-1701

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10.1038/EJHG.2016.109

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placebo

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Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial

about

P2860

P2860

Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial

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