Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. - Wikidata - awgldk - TriplyDB

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha.

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha.

http://www.wikidata.org/entity/Q37432144

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New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass.Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1.Effect of exercise intensity on isoform-specific expressions of NT-PGC-1 α mRNA in mouse skeletal muscle The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.NT-PGC-1α activation attenuates high-fat diet-induced obesity by enhancing brown fat thermogenesis and adipose tissue oxidative metabolism Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice The PGC-1 cascade as a therapeutic target for heart failure PGC-1 coactivators in the control of energy metabolism.PGC1α -1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver.Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis.Localization and regulation of the N terminal splice variant of PGC-1α in adult skeletal muscle fibers.NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis.Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α.Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α.Metabolic stress in the myocardium: adaptations of gene expression.Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.Nuclear receptor coactivators: structural and functional biochemistry.Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes.Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth.Effects of Electroacupuncture on PGC-1 α Expression in Brown Adipose Tissue Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1α.PGC-1 coactivators in cardiac development and disease

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P2860

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha.

http://www.wikidata.org/entity/Q37432144

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 September 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@en

Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@nl

type

label

Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@en

Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@nl

prefLabel

Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@en

Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@nl

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JBC.M109.037556

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Journal of Biological Chemistry

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Alternative mRNA splicing prod ...... e short isoform of PGC-1alpha.

@en

P2093

Aaron W Adamson

http://www.w3.org/2001/XMLSchema#string

Anastasia Kralli

http://www.w3.org/2001/XMLSchema#string

Anik Boudreau

http://www.w3.org/2001/XMLSchema#string

David Burk

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Jeho Shin

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Ji Suk Chang

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Johannes Klein

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Natalie R Lenard

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Nina Perwitz

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Peter Huypens

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P2860

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha

SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Activation of PPARgamma coactivator-1 through transcription factor docking

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

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32813-32826

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scholarly article

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10.1074/JBC.M109.037556

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P407

P433

47

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P478

284

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Mathias Fasshauer

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2009-09-22T00:00:00Z

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19773550

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2781698

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