Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.
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A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomicsLoss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegenerationIdentification of a functional antioxidant response element within the eighth intron of the human ABCC3 geneDual TNFα-induced effects on NRF2 mediated antioxidant defence in astrocyte-rich cultures: role of protein kinase activationSchisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathwayThe Protective Effects of Isoliquiritigenin and Glycyrrhetinic Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 ActivationPersistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulationMetabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type miceA novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune systemAnti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.Genetic polymorphism in the NRF2 gene as a prognosis marker for cancer chemotherapy.SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women.The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells.MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines.Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.Phorbaketal A, Isolated from the Marine Sponge Phorbas sp., Exerts Its Anti-Inflammatory Effects via NF-κB Inhibition and Heme Oxygenase-1 Activation in Lipopolysaccharide-Stimulated Macrophages.Aberrant Keap1 methylation in breast cancer and association with clinicopathological features.Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies.Molecular mechanisms underlying chemical liver injury.Drug metabolism alterations in nonalcoholic fatty liver diseaseRole of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transportersAntioxidant capacity of phytochemicals and their potential effects on oxidative status in animals - A review.Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease.Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells.Amomum tsao-ko suppresses lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages via Nrf2-dependent heme oxygenase-1 expression.The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes.Subtoxic and toxic concentrations of benzene and toluene induce Nrf2-mediated antioxidative stress response and affect the central carbon metabolism in lung epithelial cells A549.The transcription factor Maf-S regulates metabolic resistance to insecticides in the malaria vector Anopheles gambiae.Nrf2 Transcription Factor Can Directly Regulate mTOR: LINKING CYTOPROTECTIVE GENE EXPRESSION TO A MAJOR METABOLIC REGULATOR THAT GENERATES REDOX ACTIVITY.Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2.Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice.Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition.Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal.Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells.Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3β/NRF-2 signalling pathway.The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2.
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Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Nrf2 plays an important role i ...... d Phase III drug transporters.
@en
Nrf2 plays an important role i ...... d Phase III drug transporters.
@nl
type
label
Nrf2 plays an important role i ...... d Phase III drug transporters.
@en
Nrf2 plays an important role i ...... d Phase III drug transporters.
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prefLabel
Nrf2 plays an important role i ...... d Phase III drug transporters.
@en
Nrf2 plays an important role i ...... d Phase III drug transporters.
@nl
P2860
P356
P1476
Nrf2 plays an important role i ...... d Phase III drug transporters.
@en
P2093
Ah-Ng Kong
Guoxiang Shen
P2860
P304
P356
10.1002/BDD.680
P577
2009-10-01T00:00:00Z