The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
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In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cellsMECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes researchMicroRNAs: Novel Players in the Dialogue between Pancreatic Islets and Immune System in Autoimmune DiabetesHyaluronan: A Mediator of Islet Dysfunction and Destruction in Diabetes?Stem cell therapy to cure type 1 diabetes: from hype to hope.Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell functionMolecular mechanisms that differentiate apoptosis from programmed necrosisThe effects of diabetes on male fertility and epigenetic regulation during spermatogenesisNon-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetesIslet inflammation in plain sightNovel diabetes autoantibodies and prediction of type 1 diabetesNaturally occurring anthraquinones: chemistry and therapeutic potential in autoimmune diabetesInsulitis in human type 1 diabetes: a comparison between patients and animal modelsAltered Macrophage and Dendritic Cell Response in Mif-/- Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 DiabetesConsiderations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 DiabetesEnvironmental trigger(s) of type 1 diabetes: why so difficult to identify?The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over timeEDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting ChemicalsEpoxypukalide induces proliferation and protects against cytokine-mediated apoptosis in primary cultures of pancreatic β-cellsThe diabetes susceptibility gene Clec16a regulates mitophagySerum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 DiabetesGlibenclamide Prevents Diabetes in NOD MiceGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimEndoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalanceSTAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammationCytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activationp53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stressPeripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell deathSilencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretionAn image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouseCEBPA exerts a specific and biologically important proapoptotic role in pancreatic β cells through its downstream network targetsThe immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice.A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro.Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling.8-(Tosylamino)quinoline inhibits macrophage-mediated inflammation by suppressing NF-κB signaling.Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells
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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@en
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@nl
type
label
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@en
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@nl
prefLabel
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@en
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@nl
P356
P1476
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.
@en
P2093
Décio L Eizirik
Maikel L Colli
P2888
P304
P356
10.1038/NRENDO.2009.21
P577
2009-04-01T00:00:00Z