Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts.
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Clinical Relevance of Biomarkers of Oxidative StressLipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipidsIsoketals form cytotoxic phosphatidylethanolamine adducts in cellsA liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines.Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.New covalent modifications of phosphatidylethanolamine by alkanals: mass spectrometry based structural characterization and biological effects.Mass spectrometry detection of isolevuglandin adduction to specific protein residues.Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation.Isolevuglandin adducts in diseaseIsolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts.Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation.Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.Photo-damage, photo-protection and age-related macular degeneration.Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood.Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).Molecular Structures of Isolevuglandin-Protein Cross-Links.Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation.
P2860
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P2860
Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@en
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@nl
type
label
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@en
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@nl
prefLabel
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@en
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@nl
P2093
P2860
P1476
Isolevuglandins covalently mod ...... ysis of hydroxylactam adducts.
@en
P2093
James M Laird
John W Crabb
Laura E Nagy
Robert G Salomon
Sanjoy Roychowdhury
P2860
P304
P356
10.1016/J.FREERADBIOMED.2009.09.003
P577
2009-09-12T00:00:00Z