VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. - Wikidata - awgldk - TriplyDB

VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis.

VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis.

http://www.wikidata.org/entity/Q37443049

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Inflection points in sepsis biology: from local defense to systemic organ injury Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis.Death to sepsis: targeting apoptosis pathways in sepsis.Caspase inhibitor therapy synergizes with costimulation blockade to promote indefinite islet allograft survival.Milk fat globule EGF factor 8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats.Therapeutic interventions in sepsis: current and anticipated pharmacological agents Revisiting caspases in sepsis.Cecal ligation and puncture-induced impairment of innate immune function does not occur in the absence of caspase-1 Caspase-8 inhibition represses initial human monocyte activation in septic shock model.Apoptosis-induced lymphopenia in sepsis and other severe injuries.Rough-Form Lipopolysaccharide Increases Apoptosis in Human CD4⁺ and CD8⁺ T Lymphocytes.Recombinant human milk fat globule-EGF factor 8 produces dose-dependent benefits in sepsis.

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VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis.

http://www.wikidata.org/entity/Q37443049

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 September 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

VX-166: a novel potent small m ...... potential therapy for sepsis.

@en

VX-166: a novel potent small m ...... potential therapy for sepsis.

@nl

type

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VX-166: a novel potent small m ...... potential therapy for sepsis.

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VX-166: a novel potent small m ...... potential therapy for sepsis.

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prefLabel

VX-166: a novel potent small m ...... potential therapy for sepsis.

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VX-166: a novel potent small m ...... potential therapy for sepsis.

@nl

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VX-166: a novel potent small m ...... potential therapy for sepsis.

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Julian M C Golec

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Michael Miksa

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Michael Mortimore

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Paul Sh Wang

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Peter Charlton

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Peter Weber

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Ping Wang

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Rongqian Wu

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Stephane Maddens

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Weifeng Dong

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P2860

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate.

Cytokine dysregulation, inflammation and well-being.

The enigma of sepsis.

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