The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes
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Emerging Molecular and Biological Functions of MBD2, a Reader of DNA MethylationEpigenetic Therapeutics: A New Weapon in the War Against CancerIn vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.Statistically identifying tumor suppressors and oncogenes from pan-cancer genome-sequencing dataA recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.Expression of the dermatomyositis autoantigen transcription intermediary factor 1γ in regenerating muscle.Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.Chromatin Remodelers: From Function to Dysfunction.Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cellsDepletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formationEpigenetic alterations by NuRD and PRC2 in the neonatal mouse cochleaHelicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells.Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer.Harnessing the potential of epigenetic therapy to target solid tumors.The role of epigenetics in the biology of multiple myeloma.Methyl-CpG-binding domain proteins: readers of the epigenome.Opportunities and challenges provided by crosstalk between signalling pathways in cancer.A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes.Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cellsMethyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer.Targeting the cancer epigenome for therapy.Epigenetic Determinants of Cancer.Genetically engineered mesenchymal stromal cells producing TNFα have tumour suppressing effect on human melanoma xenograft.Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Enzymology of Mammalian DNA Methyltransferases.Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3B.CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes.Covalent Modifications of Histone H3K9 Promote Binding of CHD3.Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer.Prognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients.Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.
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The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The NuRD complex cooperates wi ...... orectal tumor suppressor genes
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The NuRD complex cooperates wi ...... rectal tumor suppressor genes.
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type
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The NuRD complex cooperates wi ...... orectal tumor suppressor genes
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The NuRD complex cooperates wi ...... rectal tumor suppressor genes.
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The NuRD complex cooperates wi ...... orectal tumor suppressor genes
@en
The NuRD complex cooperates wi ...... rectal tumor suppressor genes.
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The NuRD complex cooperates wi ...... orectal tumor suppressor genes
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E-J Geutjes
H Mohammad
J van Blijswijk
S B Baylin
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10.1038/ONC.2013.178
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2013-05-27T00:00:00Z