Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls.
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Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111)Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug designStructural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10Aldo-Keto Reductases 1B in Adrenal Cortex PhysiologyGenome-wide and differential proteomic analysis of hepatitis B virus and aflatoxin B1 related hepatocellular carcinoma in Guangxi, ChinaGlobal Proteome Changes in the Rat Diaphragm Induced by Endurance Exercise Training.Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment.Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals.High expression of aldo-keto reductase 1B10 is an independent predictor of favorable prognosis in patients with hepatocellular carcinomaChoriodecidual infection downregulates angiogenesis and morphogenesis pathways in fetal lungs from Macaca nemestrinaGene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosisAcridone derivative 8a induces oxidative stress-mediated apoptosis in CCRF-CEM leukemia cells: application of metabolomics in mechanistic studies of antitumor agents.Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group.Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice.Genetic variants in AKR1B10 associate with human eating behavior.Novel chemical scaffolds of the tumor marker AKR1B10 inhibitors discovered by 3D QSAR pharmacophore modeling.Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-α pathway activity in mice.Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.Aldo-Keto Reductases 1B in Endocrinology and Metabolism.Regulation of aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma.Low expression of Aldo-keto reductase 1B10 is a novel independent prognostic indicator for nasopharyngeal carcinoma.Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate.Heat shock protein 90-α mediates aldo-keto reductase 1B10 (AKR1B10) protein secretion through secretory lysosomes.AKR1B10 promotes breast cancer metastasis through integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway.Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells.Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis.A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation.Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathwayEpalrestat increases intracellular glutathione levels in Schwann cells through transcription regulation.Structural basis for the inhibition of AKR1B10 by caffeic acid phenethyl ester (CAPE).AKR1B10 overexpression in breast cancer: association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker.Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma.Nano-LC-MS/MS based proteomics of hepatocellular carcinoma cells compared to Chang liver cells and tanshinone IIA induction.Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds.Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant CancersEffects of ligand binding on the stability of aldo-keto reductases: Implications for stabilizer or destabilizer chaperones.Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway.Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.
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Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 30 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@en
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@nl
type
label
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@en
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@nl
prefLabel
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@en
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@nl
P2093
P2860
P356
P1476
Aldo-keto reductase family 1 m ...... sis and eliminating carbonyls.
@en
P2093
Deliang Cao
Dixian Luo
Duan-Fang Liao
Kounosuke Watabe
Ruilan Yan
P2860
P304
26742-26748
P356
10.1074/JBC.M109.022897
P407
P577
2009-07-30T00:00:00Z