Sodium channel mutations and arrhythmias. - Wikidata - awgldk - TriplyDB

Sodium channel mutations and arrhythmias.

Sodium channel mutations and arrhythmias.

http://www.wikidata.org/entity/Q37450777

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A connexin40 mutation associated with a malignant variant of progressive familial heart block type I Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites The role of late I Na in development of cardiac arrhythmias Channelopathies from mutations in the cardiac sodium channel protein complex Ion Channels in the Heart The molecular autopsy: should the evaluation continue after the funeral?Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes Crystallographic basis for calcium regulation of sodium channels The cardiac conduction system Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia.Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction.Targeted analysis of whole genome sequence data to diagnose genetic cardiomyopathy.A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations Genetic variants in SCN5A promoter are associated with arrhythmia phenotype severity in patients with heterozygous loss-of-function mutation Genetic testing of inherited arrhythmias.Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome.Targeting device therapy: genomics of sudden death.TRPM1 mutations are associated with the complete form of congenital stationary night blindness Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.Re-evaluation of the action potential upstroke velocity as a measure of the Na+ current in cardiac myocytes at physiological conditions.Genome-wide association studies in cardiac electrophysiology: recent discoveries and implications for clinical practice Location, location, regulation: a novel role for β-spectrin in the heart.Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.Kinetic model of Nav1.5 channel provides a subtle insight into slow inactivation associated excitability in cardiac cells.Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.Genetics of atrial fibrillation and possible implications for ischemic stroke.Deletion of PDK1 causes cardiac sodium current reduction in mice Teaching the pharmacology of antiarrhythmic drugs.Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy Common genetic variants associated with sudden cardiac death: the FinSCDgen study.Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes.Risk factors and outcomes associated with new-onset atrial fibrillation during acute respiratory distress syndrome.The genetics of sudden cardiac death.Biology of the Sinus Node and its Disease.

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Sodium channel mutations and arrhythmias.

http://www.wikidata.org/entity/Q37450777

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bilimsel makale

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scientific article published on May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Sodium channel mutations and arrhythmias.

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Sodium channel mutations and arrhythmias.

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Sodium channel mutations and arrhythmias.

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Sodium channel mutations and arrhythmias.

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Sodium channel mutations and arrhythmias.

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Sodium channel mutations and arrhythmias.

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NRCARDIO.2009.44

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Nature Reviews Cardiology

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Sodium channel mutations and arrhythmias.

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Nian Liu

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Silvia G Priori

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Yanfei Ruan

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P2860

Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel

A single Na(+) channel mutation causing both long-QT and Brugada syndromes

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)

Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families.

Prevalence of paroxysmal atrial fibrillation in Brugada syndrome: a case series and a review of the literature.

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation.

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation

Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.

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nrcardio.2009.44

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