Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1.
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Role of EBNA-3 Family Proteins in EBV Associated B-cell LymphomagenesisEpstein-Barr virus latent genesThe EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growthEpigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification.Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines.Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression.Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes.Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth.Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cellsEBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B CellsEpstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic SitesERK2 phosphorylation of EBNA1 serine 383 residue is important for EBNA1-dependent transactivationEpstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A.Impact of EBV essential nuclear protein EBNA-3C on B-cell proliferation and apoptosis.Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation.An EBV recombinant deleted for residues 130-159 in EBNA3C can deregulate p53/Mdm2 and Cyclin D1/CDK6 which results in apoptosis and reduced cell proliferation.RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia.The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency.Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of and the Locus via Interaction with the Histone Lysine Demethylase KDM2B
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Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 September 2009
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vedecký článok
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vetenskaplig artikel
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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P2093
P2860
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Epstein-Barr virus nuclear pro ...... ith RBP-Jkappa regulates TCL1.
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Amy M Holthaus
Chiou-Yan Lai
Eric Johannsen
Kenzo Takada
Michael A Calderwood
Seiji Maruo
Shuhei Sakakibara
Sungwook Lee
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P304
12368-12377
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10.1128/JVI.01403-09
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P577
2009-09-23T00:00:00Z