The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.
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Post-Translational Modifications of RelB NF-κB Subunit and Associated FunctionsHistone methylation modifiers in cellular signaling pathwaysThe RelB subunit of NFκB acts as a negative regulator of circadian gene expressionDynamic and selective nucleosome repositioning during endotoxin tolerance.Chemical probes targeting epigenetic proteins: Applications beyond oncology.Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences.IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study.MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance.Dynamic modulation of innate immune response by varying dosages of lipopolysaccharide (LPS) in human monocytic cells.Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells.IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcomeClassical NF-kappaB activation negatively regulates noncanonical NF-kappaB-dependent CXCL12 expression.Microglial phenotype and adaptation.Citrullination of histone H3 interferes with HP1-mediated transcriptional repression.Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsisNAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.Dark matters in AMD genetics: epigenetics and stochasticityA silent exonic SNP in kdm3a affects nucleic acids structure but does not regulate experimental autoimmune encephalomyelitis.MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming.Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation.A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing.Moderate activation of IKK2-NF-kB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis.G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinomaMolecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharideRelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?Fueling the flame: bioenergy couples metabolism and inflammation.Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia.The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formationPellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation.Molecular mechanism responsible for the priming of macrophage activation.Endotoxin tolerance in monocytes can be mitigated by α2-interferonRestricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer.Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages.Role of macrophage receptor with collagenous structure in innate immune tolerance.MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.RelB: an outlier in leukocyte biology.
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The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@en
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@nl
type
label
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@en
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@nl
prefLabel
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@en
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@nl
P2093
P2860
P356
P1476
The NF-kappaB factor RelB and ...... encing in endotoxin tolerance.
@en
P2093
Barbara K Yoza
Charles E McCall
Mohamed El Gazzar
Xiaoping Chen
P2860
P304
27857-27865
P356
10.1074/JBC.M109.000950
P407
P577
2009-08-18T00:00:00Z