Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. - Wikidata - awgldk - TriplyDB

Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

http://www.wikidata.org/entity/Q37467551

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Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids.Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation.Regulation of lipid metabolism: a tale of two yeasts.The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.Regulation of HMG-CoA reductase in mammals and yeast Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein.Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast.The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis.Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae.The protein quality control system manages plant defence compound synthesis.A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.Proteostatic Tactics in the Strategy of Sterol Regulation.Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors.Geranylgeranyl pyrophosphate is crucial for neuronal survival but has no special role in Purkinje cell degeneration in Niemann Pick type C1 disease.The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.Insight into yeast: A study model of lipid metabolism and terpenoid biosynthesis.Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.Mallostery: Filling a niche between quality and metabolic control

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Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

http://www.wikidata.org/entity/Q37467551

description

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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JBC.M109.023994

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Journal of Biological Chemistry

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Geranylgeranyl pyrophosphate i ...... eductase degradation in yeast.

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Peter N Tran

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Randolph Y Hampton

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Renee M Garza

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P2860

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Reconstitution of retrograde transport from the Golgi to the ER in vitro.

BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae.

INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins

Protein prenyltransferases

Geranylgeranyl diphosphate synthase in fission yeast is a heteromer of farnesyl diphosphate synthase (FPS), Fps1, and an FPS-like protein, Spo9, essential for sporulation

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.

Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p.

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35368-35380

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scholarly article

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10.1074/JBC.M109.023994

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51

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284

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2009-12-01T00:00:00Z

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19776008

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2790966

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