MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
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Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccinationImmune signaling by RIG-I-like receptorsGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimNovel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease backgroundMicroRNA expression signature in human abdominal aortic aneurysmsDifferential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cellsOn the immense variety and complexity of circumstances conditioning pancreatic β-cell apoptosis in type 1 diabetesShared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 DiabetesUSP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosisAncient origins of vertebrate-specific innate antiviral immunity.Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice.The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?Viral infections in type 1 diabetes mellitus--why the β cells?The genetics of innate immunity sensors and human disease.Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes.Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis.The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus.Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.Genes affecting β-cell function in type 1 diabetes.The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy.Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis.Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis.Enteroviruses and Type 1 Diabetes: Candidate Genes Linked With Innate Immune ResponseType 1 diabetes genome-wide association studies: not to be lost in translation.Pancreatic Beta Cell Survival and Signaling Pathways: Effects of Type 1 Diabetes-Associated Genetic Variants.Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation
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MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@en
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@nl
type
label
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@en
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@nl
prefLabel
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@en
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@nl
P2093
P2860
P356
P1476
MDA5 and PTPN2, two candidate ...... y-product double-stranded RNA.
@en
P2093
Decio L Eizirik
Fabrice Moore
Maikel L Colli
P2860
P304
P356
10.1093/HMG/DDP474
P577
2010-01-01T00:00:00Z