Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. - Wikidata - awgldk - TriplyDB

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration.

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration.

http://www.wikidata.org/entity/Q37471792

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What can we learn about autism from studying fragile X syndrome?Fragile X spectrum disorders Fragile X-associated tremor/ataxia syndrome.Unstable mutations in the FMR1 gene and the phenotypes Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders The role of AGG interruptions in the transcription of FMR1 premutation alleles Neural substrates of executive dysfunction in fragile X-associated tremor/ataxia syndrome (FXTAS): a brain potential study.Fragile X: leading the way for targeted treatments in autism.CGG repeat in the FMR1 gene: size matters Fragile X: a family of disorders.Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size.Broad clinical involvement in a family affected by the fragile X premutation.Epilepsy drives autism in neurodevelopmental disorders.Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.Advances in understanding the molecular basis of FXTAS Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder.Sleep apnea in fragile X premutation carriers with and without FXTAS.Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans.Genomic studies in fragile X premutation carriers.Fragile X and autism: Intertwined at the molecular level leading to targeted treatments.CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development.A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR Molecular Advances Leading to Treatment Implications for Fragile X Premutation Carriers A voxel-based morphometry study of grey matter loss in fragile X-associated tremor/ataxia syndrome.CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS Current research, diagnosis, and treatment of fragile X-associated tremor/ataxia syndrome.Addictive substances may induce a rapid neurological deterioration in fragile X-associated tremor ataxia syndrome: A report of two cases Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice Mouse models of the fragile x premutation and the fragile X associated tremor/ataxia syndrome.A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS.Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation Immune dysregulation as a cause of autoinflammation in fragile X premutation carriers: link between FMRI CGG repeat number and decreased cytokine responses.A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis.

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Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration.

http://www.wikidata.org/entity/Q37471792

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2010

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Murine hippocampal neurons exp ...... eficits and late degeneration.

@en

Murine hippocampal neurons exp ...... eficits and late degeneration.

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type

label

Murine hippocampal neurons exp ...... eficits and late degeneration.

@en

Murine hippocampal neurons exp ...... eficits and late degeneration.

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prefLabel

Murine hippocampal neurons exp ...... eficits and late degeneration.

@en

Murine hippocampal neurons exp ...... eficits and late degeneration.

@nl

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Human Molecular Genetics

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Murine hippocampal neurons exp ...... eficits and late degeneration.

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Flora Tassone

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Isaac N Pessah

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Paul J Hagerman

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Randi J Hagerman

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Rob Willemsen

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Robert F Berman

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Yucui Chen

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P2860

The fragile-X premutation: a maturing perspective.

Advances in the treatment of fragile X syndrome

A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome.

NS21: re-defined and modified supplement B27 for neuronal cultures

Diversity and dynamics of dendritic signaling

Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox

SynGAP regulates spine formation

The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome

Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.

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196-208

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scholarly article

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10.1093/HMG/DDP479

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1

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P478

19

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2010-01-01T00:00:00Z

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38027349

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19846466

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2792156

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