Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein. - Wikidata - awgldk - TriplyDB

Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.

Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.

http://www.wikidata.org/entity/Q37474224

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Advances of Molecular Imaging in Epilepsy PET radiotracers: crossing the blood-brain barrier and surviving metabolism Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography.Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)Reproducibility of quantitative (R)-[11C]verapamil studies.Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies.Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy.Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications.P-glycoprotein related drug interactions: clinical importance and a consideration of disease states.Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function.

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Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.

http://www.wikidata.org/entity/Q37474224

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article científic

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bilimsel makale

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scientific article published on 16 April 2009

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Human brain imaging and radiat ...... he function of P-glycoprotein.

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Human brain imaging and radiat ...... he function of P-glycoprotein.

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Human brain imaging and radiat ...... he function of P-glycoprotein.

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Human brain imaging and radiat ...... he function of P-glycoprotein.

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JNUMED.108.058453

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The Journal of Nuclear Medicine

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Human brain imaging and radiat ...... he function of P-glycoprotein.

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Andrew Taku

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Jeih-San Liow

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Kimberly Jenko

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Nicholas Seneca

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Peter Herscovitch

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Robert B Innis

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Robert L Gladding

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Sami S Zoghbi

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Victor W Pike

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William Kreisl

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P2860

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis.

Importance of P-glycoprotein at blood-tissue barriers.

Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses

Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function

P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil.

Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation.

PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements.

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807-813

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scholarly article

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10.2967/JNUMED.108.058453

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desmethyl loperamide

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