Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.
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Advances of Molecular Imaging in EpilepsyPET radiotracers: crossing the blood-brain barrier and surviving metabolismEffects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography.Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)Reproducibility of quantitative (R)-[11C]verapamil studies.Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrierA novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrierPhysiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approachSuggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies.Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy.Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications.P-glycoprotein related drug interactions: clinical importance and a consideration of disease states.Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function.
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Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Human brain imaging and radiat ...... he function of P-glycoprotein.
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Human brain imaging and radiat ...... he function of P-glycoprotein.
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type
label
Human brain imaging and radiat ...... he function of P-glycoprotein.
@en
Human brain imaging and radiat ...... he function of P-glycoprotein.
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prefLabel
Human brain imaging and radiat ...... he function of P-glycoprotein.
@en
Human brain imaging and radiat ...... he function of P-glycoprotein.
@nl
P2093
P2860
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Human brain imaging and radiat ...... he function of P-glycoprotein.
@en
P2093
Andrew Taku
Jeih-San Liow
Kimberly Jenko
Nicholas Seneca
Peter Herscovitch
Robert B Innis
Robert L Gladding
Sami S Zoghbi
Victor W Pike
William Kreisl
P2860
P304
P356
10.2967/JNUMED.108.058453
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P577
2009-04-16T00:00:00Z