Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut.
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Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids.Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular targetAdipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptakePlasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are relatedMembrane docosahexaenoate is supplied to the developing brain and retina by the liver.3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptakeRegulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization.Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake.Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gutKeap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissuePathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.Storage rates of circulating free fatty acid into adipose tissue during eating or walking in humans.Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet.At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle.Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss.Regulated membrane transport of free fatty acids in adipocytes: role in obesity and non-insulin dependent diabetes mellitus.Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence.Nonalcoholic Fatty Liver Disease: Lipids and Insulin Resistance.Intramuscular lipid metabolism, insulin action, and obesity.pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids.Plasma levels, tissue distribution, and excretion of radioactivity after single-dose administration of ((3)H)-oleic acid added to D-004, a lipid extract of the fruit of Roystonea regia, in ratsExpression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport.Recent studies of the cellular uptake of long chain free fatty acids.Molecular modeling and functional confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase.Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.The influence of placental metabolism on fatty acid transfer to the fetus.Fatty acid transport in adipocytes monitored by imaging intracellular free fatty acid levels.Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA.Saturation kinetics of palmitate uptake in perfused skeletal muscle.The effect of intracellular pH on long-chain fatty acid uptake in 3T3-L1 adipocytes: evidence that uptake involves the passive diffusion of protonated long-chain fatty acids across the plasma membrane.Transport of 13C-oleate in adipocytes measured using multi imaging mass spectrometry.Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes.Effect of dexamethasone, 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation.Hepatocellular fatty acid uptake is mediated by a plasma membrane fatty acid binding protein closely related to mitochondrial glutamic oxaloacetic transaminase.Contraction-induced increase in Vmax of palmitate uptake and oxidation in perfused skeletal muscle.Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B/Pl rats in response to high-fat diets.Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity.
P2860
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P2860
Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1988
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@en
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@nl
type
label
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@en
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@nl
prefLabel
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@en
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@nl
P2093
P2860
P356
P1476
Uptake of oleate by isolated r ...... ated to that in liver and gut.
@en
P2093
B J Potter
D Sorrentino
W Schwieterman
P2860
P304
P356
10.1073/PNAS.85.2.359
P407
P577
1988-01-01T00:00:00Z