Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
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The crosstalk of mTOR/S6K1 and Hedgehog pathwaysThe structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingThe hedgehog receptor patched is involved in cholesterol transportPharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein bindingCD200-expressing human basal cell carcinoma cells initiate tumor growthTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsAberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceCommon stemness regulators of embryonic and cancer stem cellsHedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic SignalingThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseNovel agents for advanced pancreatic cancerIns and outs of GPCR signaling in primary ciliaHedgehog Signaling in the Maintenance of Cancer Stem CellsCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyHedgehog signaling inhibitors as anti-cancer agents in osteosarcomaSonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the benchSonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activityStromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerStructure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingIn vitro models of cancer stem cells and clinical applicationsPrediction of Bacillus Calmette-Guerin Response in Patients with Bladder Cancer after Transurethral Resection of Bladder Tumor by Using Genetic Variation Based on Genomic StudiesMolecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cellsParacrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironmentA novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelA novel PEGylated liposome-encapsulated SANT75 suppresses tumor growth through inhibiting hedgehog signaling pathwayHedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clustersIdentifying and targeting cancer stem cells in the treatment of gastric cancer.Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane proteinTargeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.Classification of genes and putative biomarker identification using distribution metrics on expression profilesChemical and biological studies of nakiterpiosin and nakiterpiosinone.Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatmentAnalysis of axonal trafficking via a novel live-imaging technique reveals distinct hedgehog transport kineticsA novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fieldsUp-regulation of sonic hedgehog contributes to TGF-β1-induced epithelial to mesenchymal transition in NSCLC cellsThe emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Inhibition of hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells.
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P2860
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
@en
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
@nl
type
label
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
@en
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
@nl
prefLabel
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
@en
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
@nl
P1476
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
@en
P2093
Frederic J de Sauvage
P304
P356
10.1016/J.TIPS.2009.03.007
P577
2009-05-13T00:00:00Z