The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease.
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Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's DiseaseAlzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasisDynamic self-guiding analysis of Alzheimer's disease.The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Role of iron in neurodegenerative diseases.Hepcidin antagonists for potential treatments of disorders with hepcidin excess.Analyzing the genes related to Alzheimer's disease via a network and pathway-based approachDisrupted iron regulation in the brain and periphery in cocaine addictionTargeting iron metabolism in drug discovery and deliveryThe novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's diseaseIron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy.Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice.Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.Dopaminergic Neurons Respond to Iron-Induced Oxidative Stress by Modulating Lipid Acylation and Deacylation Cycles.Modulation of hepcidin to treat iron deregulation: potential clinical applications.Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid β accumulation in cognitively normal subjects.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Hepcidin and its potential clinical utility.Iron and dopamine: a toxic couple.Hepcidin: Homeostasis and Diseases Related to Iron Metabolism.Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases.The liver in regulation of iron homeostasis.Shared mechanisms of neurodegeneration in Alzheimer's disease and Parkinson's disease.Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia.Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.Hepcidin: a real-time biomarker of iron need.Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.Hepcidin, an emerging and important player in brain iron homeostasis.Cu(atsm) Attenuates NeuroinflammationThe Dual Role of Hepcidin in Brain Iron Load and InflammationColocalization of Aluminum and Iron in Nuclei of Nerve Cells in Brains of Patients with Alzheimer's DiseaseIn Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity
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The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
@en
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
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type
label
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
@en
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
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prefLabel
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
@en
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
@nl
P2093
P2860
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P1476
The systemic iron-regulatory p ...... brain in Alzheimer's disease.
@en
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Adrian Bomford
Animesh Alexander Raha
Radhika Anand Vaishnav
Robert Paul Friedland
Ruma Raha-Chowdhury
P2860
P2888
P356
10.1186/2051-5960-1-55
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2013-09-03T00:00:00Z
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P6179
1047661792