Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.
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DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaBDJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADDSubstrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CThe caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS productionIdentification of the novel substrates for caspase-6 in apoptosis using proteomic approaches.L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairmentsAlternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development.Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Identification and characterization of an oocyte factor required for development of porcine nuclear transfer embryos.Expression and activation of caspase-6 in human fetal and adult tissuesOxidized DJ-1 interacts with the mitochondrial protein BCL-XL.APC +/- alters colonic fibroblast proteome in FAP.An optimized activity-based probe for the study of caspase-6 activation.L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.Direct α-synuclein promoter transactivation by the tumor suppressor p53.P73 and age-related diseases: is there any link with Parkinson Disease?Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer diseaseUnderstanding the molecular basis of Parkinson's disease, identification of biomarkers and routes to therapy.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.Adiponectin offers protection against L166P mutant DJ-1-induced neuronal cytotoxicity mediated by APPL1-dependent AMPK activation.Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease.Caspase-6 latent state stability relies on helical propensity.Consequences of DJ-1 upregulation following p53 loss and cell transformation.Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2.The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control.Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.
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Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@en
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@nl
type
label
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@en
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@nl
prefLabel
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@en
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@nl
P2093
P2860
P356
P1476
Loss of function of DJ-1 trigg ...... lytic resistance to caspase-6.
@en
P2093
C Alves da Costa
M S Goldberg
P Auberger
P2860
P2888
P304
P356
10.1038/CDD.2009.116
P577
2010-01-01T00:00:00Z
P5875
P6179
1034284237