Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.
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Detection of 2-hydroxyglutarate in brain tumors by triple-refocusing MR spectroscopy at 3T in vivo.Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgeryHominoid-specific enzyme GLUD2 promotes growth of IDH1R132H gliomaTowards imaging metabolic pathways in tissues.A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeresMitochondrial DNA copy number variation across human cancersGlioma: experimental models and reality.Proteomics and metabolomics in cancer drug development.Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of gliomaApplications of Mass Spectrometry Imaging for Safety Evaluation.Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase.Profiling of the metabolic transcriptome via single molecule molecular inversion probes.The NADP+-dependent IDH1 mutation and its relevance for glioblastoma patient survival.Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.Wild-type and mutated IDH1/2 enzymes and therapy responses.The angiogenic switch leads to a metabolic shift in human glioblastoma.IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity.IDH1 is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment
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Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 May 2013
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@en
Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@nl
type
label
Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@en
Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@nl
prefLabel
Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@en
Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@nl
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Increased mitochondrial activi ...... tu detection of 2-HG and α-KG.
@en
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Alan Wright
Arno van Rooij
Cornelis J F van Noorden
Daniel Stieber
Irene Otte-Holler
Jonathan Stauber
Kiek Verrijp
Ron A Wevers
Sanne van Lith
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P2888
P356
10.1186/2051-5960-1-18
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P577
2013-05-29T00:00:00Z
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P6179
1051487405