Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
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The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural developmentModifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseasePhysiological and pathological implications of 5-hydroxymethylcytosine in diseasesRationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor CellsPluripotent Stem Cells: Current Understanding and Future DirectionsMetaboloepigenetic Regulation of Pluripotent Stem CellsFunctions of TET Proteins in Hematopoietic TransformationAscorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progressionDNA modifications: function and applications in normal and disease StatesChromatin features and the epigenetic regulation of pluripotency states in ESCsConnections between TET proteins and aberrant DNA modification in cancerRegulation of the Epigenome by Vitamin CMechanism and function of oxidative reversal of DNA and RNA methylationThe TET2 interactors and their links to hematological malignanciesChromatin dynamics during cellular reprogrammingStructural insight into substrate preference for TET-mediated oxidationRole of TET enzymes in DNA methylation, development, and cancerDNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic DisordersEpigenetics in liver disease: from biology to therapeuticsDNA methylation and hydroxymethylation in stem cellsProperties and biological roles of TET proteins during embryogenesis and in hematopoiesisMEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cellsBase-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seqAscorbic acid and the brain: rationale for the use against cognitive decline.Reprogramming towards totipotency is greatly facilitated by synergistic effects of small moleculesVitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics.Hydroxymethylation as a Novel Environmental BiosensorReprogramming the methylome: erasing memory and creating diversity.Next-generation mammalian genetics toward organism-level systems biologyActivation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum.The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states.Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression.Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.Mechanisms for enhancing cellular reprogrammingThe use of small molecules in somatic-cell reprogramming.Human pancreatic beta-like cells converted from fibroblasts.Chemically defined generation of human cardiomyocytesSetdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cellsNANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes
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Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 June 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@en
Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@nl
type
label
Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@en
Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@nl
prefLabel
Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@en
Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@nl
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Vitamin C induces Tet-dependen ...... tocyst-like state in ES cells.
@en
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Angela Tam
Anjana Rao
Diana J Laird
Jorge A Zepeda-Martínez
Kathryn Blaschke
Martin Hirst
Miguel Ramalho-Santos
Preeti Goyal
Sahasransu Mahapatra
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10.1038/NATURE12362
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P577
2013-06-30T00:00:00Z
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1008910662