Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. - Wikidata - awgldk - TriplyDB

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

http://www.wikidata.org/entity/Q37491590

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Uncleaved TFIIA is a substrate for taspase 1 and active in transcription General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2 Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs The tetraspan protein EMP2 regulates expression of caveolin-1.Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.TBP-like protein (TLP) interferes with Taspase1-mediated processing of TFIIA and represses TATA box gene expression.Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.Disease-relevant signalling-pathways in head and neck cancer: Taspase1's proteolytic activity fine-tunes TFIIA function.TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch.

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Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

http://www.wikidata.org/entity/Q37491590

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 15 July 2004

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

@en

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

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type

label

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

@en

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

@nl

prefLabel

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

@en

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

@nl

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SJ.EMBOJ.7600304

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The EMBO Journal

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Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

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Dimitra J Mitsiou

http://www.w3.org/2001/XMLSchema#string

Hendrik G Stunnenberg

http://www.w3.org/2001/XMLSchema#string

Huiqing Zhou

http://www.w3.org/2001/XMLSchema#string

Torill Høiby

http://www.w3.org/2001/XMLSchema#string

P2860

TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family

Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis

Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription

Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription

Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription

Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

The N-end rule: functions, mysteries, uses

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids

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3083-3091

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scholarly article

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10.1038/SJ.EMBOJ.7600304

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15

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23

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Hediye Erdjument-Bromage

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2004-07-15T00:00:00Z

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8452873

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15257296

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514921

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