Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. - Wikidata - awgldk - TriplyDB

Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy.

Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy.

http://www.wikidata.org/entity/Q37491704

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Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex Structural changes enable start codon recognition by the eukaryotic translation initiation complex.Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex.Mechanism of cytoplasmic mRNA translation.The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons.eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast.Non-AUG translation: a new start for protein synthesis in eukaryotes.eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex.

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Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy.

http://www.wikidata.org/entity/Q37491704

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 December 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Enhanced eIF1 binding to the 4 ...... elevates initiation accuracy.

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Enhanced eIF1 binding to the 4 ...... elevates initiation accuracy.

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type

label

Enhanced eIF1 binding to the 4 ...... elevates initiation accuracy.

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Enhanced eIF1 binding to the 4 ...... elevates initiation accuracy.

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prefLabel

Enhanced eIF1 binding to the 4 ...... elevates initiation accuracy.

@en

Enhanced eIF1 binding to the 4 ...... elevates initiation accuracy.

@nl

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Enhanced eIF1 binding to the 4 ...... d elevates initiation accuracy

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Alan G Hinnebusch

http://www.w3.org/2001/XMLSchema#string

Fan Zhang

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Gerhard Wagner

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Jagpreet S Nanda

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Pilar Martin-Marcos

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Rafael E Luna

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Vera A Cherkasova

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P2860

The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons

Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selection

Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1

The initiation of mammalian protein synthesis and mRNA scanning mechanism

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon.

Efficient incorporation of eukaryotic initiation factor 1 into the multifactor complex is critical for formation of functional ribosomal preinitiation complexes in vivo.

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150-167

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scholarly article

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10.1261/RNA.042069.113

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2

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20

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2013-12-13T00:00:00Z

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259320158

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24335188

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3895268

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