TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
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Temperature sensitivity of two-pore (K2P) potassium channelsMolecular mechanisms of temperature adaptationPolymodal activation of the TREK-2 K2P channel produces structurally distinct open statesIon channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission.Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel.Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root GanglionIntersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2.Effects of analgesics and antidepressants on TREK-2 and TRESK currentsFxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain.Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators.Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.Identification of critical amino acids in the proximal C-terminal of TREK-2 K(+) channel for activation by acidic pHi and ATP-dependent inhibition.Roles of isolectin B4-binding afferents in colorectal mechanical nociception.The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain.GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias.PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.TRPs et al.: a molecular toolkit for thermosensory adaptations.Mechanism of Mechanosensitive Gating of the TREK-2 Potassium Channel.Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats.
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P2860
TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
TREK2 expressed selectively in ...... s and limits spontaneous pain.
@en
TREK2 expressed selectively in ...... s and limits spontaneous pain.
@nl
type
label
TREK2 expressed selectively in ...... s and limits spontaneous pain.
@en
TREK2 expressed selectively in ...... s and limits spontaneous pain.
@nl
prefLabel
TREK2 expressed selectively in ...... s and limits spontaneous pain.
@en
TREK2 expressed selectively in ...... s and limits spontaneous pain.
@nl
P2093
P2860
P1476
TREK2 expressed selectively in ...... ls and limits spontaneous pain
@en
P2093
Carol Berry
Kirsty Bromage
Laiche Djouhri
Roger Watkins
Sally N Lawson
P2860
P304
P356
10.1523/JNEUROSCI.4528-13.2014
P407
P577
2014-01-01T00:00:00Z