Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. - Wikidata - awgldk - TriplyDB

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

http://www.wikidata.org/entity/Q37507076

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Don't stress about CRF: assessing the translational failures of CRF1antagonists.Structural Analysis of Chemokine Receptor-Ligand Interactions.Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.What Do Structures Tell Us About Chemokine Receptor Function and Antagonism?GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors.Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa.Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.Methods for Virtual Screening of GPCR Targets: Approaches and Challenges.Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy.Discovery of new GPCR ligands to illuminate new biology.Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics Simulations.Chemokines from a Structural Perspective.Biased signalling: from simple switches to allosteric microprocessors.Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.Interaction of Monomeric Interleukin-8 with CXCR1 Mapped by Proton-Detected Fast MAS Solid-State NMR.Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?Current and Future Challenges in GPCR Drug Discovery.Enhancing Structure Prediction and Design of Soluble and Membrane Proteins with Explicit Solvent-Protein Interactions.Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre-metastatic niche through activating β-adrenergic signaling.Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4.Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys-197 and by transmembrane protein aptamers that target it for lysosomal degradation.Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol.In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease.Pharmacology: Inside-out receptor inhibition.A guide to chemokines and their receptors.Shining Light on Molecular Mechanism for Odor-selectivity of CNT-immobilized Olfactory Receptor.G protein-coupled receptors: the evolution of structural insight.Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor.PtdIns(4,5)P stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

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Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

http://www.wikidata.org/entity/Q37507076

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 December 2016

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@en

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@nl

type

label

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@en

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@nl

prefLabel

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@en

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@nl

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P1476

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

@en

P2093

Adriaan P IJzerman

http://www.w3.org/2001/XMLSchema#string

Andrew Tebben

http://www.w3.org/2001/XMLSchema#string

Chunxia Zhao

http://www.w3.org/2001/XMLSchema#string

Dean Stamos

http://www.w3.org/2001/XMLSchema#string

Gye Won Han

http://www.w3.org/2001/XMLSchema#string

Henk de Vries

http://www.w3.org/2001/XMLSchema#string

Ling Qin

http://www.w3.org/2001/XMLSchema#string

Marta Dabros

http://www.w3.org/2001/XMLSchema#string

Natalia V Ortiz Zacarías

http://www.w3.org/2001/XMLSchema#string

Percy Carter

http://www.w3.org/2001/XMLSchema#string

P2860

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

Crystal structure of the β2 adrenergic receptor-Gs protein complex

MolProbity: all-atom structure validation for macromolecular crystallography

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

Specific chemical and structural damage to proteins produced by synchrotron radiation

Crystal structure of rhodopsin: A G protein-coupled receptor

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

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458-461

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scholarly article

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10.1038/NATURE20605

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P433

7633

http://www.w3.org/2001/XMLSchema#string

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540

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Raymond C Stevens

Laura H Heitman

Martin Gustavsson

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2016-12-07T00:00:00Z

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27926736

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5159191

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