AIPL1, A protein linked to blindness, is essential for the stability of enzymes mediating cGMP metabolism in cone photoreceptor cells.
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Early alteration of retinal neurons in Aipl1-/- animals.Gene Therapy Fully Restores Vision to the All-Cone Nrl(-/-) Gucy2e(-/-) Mouse Model of Leber Congenital Amaurosis-1.Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor FunctionARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish.Mouse models of human ocular disease for translational research.The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6.AIPL1: A specialized chaperone for the phototransduction effector.Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches.How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration.
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AIPL1, A protein linked to blindness, is essential for the stability of enzymes mediating cGMP metabolism in cone photoreceptor cells.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
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AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
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type
label
AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
@en
AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
@nl
prefLabel
AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
@en
AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
@nl
P2860
P356
P1476
AIPL1, A protein linked to bli ...... m in cone photoreceptor cells.
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P2093
Ratnesh K Singh
Saravanan Kolandaivelu
P2860
P304
P356
10.1093/HMG/DDT496
P577
2013-10-09T00:00:00Z