Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. - Wikidata - awgldk - TriplyDB

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

http://www.wikidata.org/entity/Q37510143

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Programming of fetal insulin resistance in pregnancies with maternal obesity by ER stress and inflammation Emerging issues in radiogenic cataracts and cardiovascular disease Potential role for snoRNAs in PKR activation during metabolic stress A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes.Design and synthesis of novel protein kinase R (PKR) inhibitors.Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance.Double-stranded RNA-dependent protein kinase signalling and paradigms of cardiometabolic syndrome.Clinical and therapeutic potential of protein kinase PKR in cancer and metabolism.Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds.Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects.Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival.Manifestations and mechanisms of myocardial lipotoxicity in obesity.

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Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

http://www.wikidata.org/entity/Q37510143

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 October 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

@en

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

@nl

type

label

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

@en

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

@nl

prefLabel

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

@en

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

@nl

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Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice

@en

P2093

Brenna Baccaro

http://www.w3.org/2001/XMLSchema#string

Gökhan S Hotamisligil

http://www.w3.org/2001/XMLSchema#string

Masato Furuhashi

http://www.w3.org/2001/XMLSchema#string

Takahisa Nakamura

http://www.w3.org/2001/XMLSchema#string

P2860

Inflammation and insulin resistance

Novel role of PKR in inflammasome activation and HMGB1 release

Inflammation and metabolic disorders

Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

IKK-beta links inflammation to obesity-induced insulin resistance

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

A central role for JNK in obesity and insulin resistance

Small molecule inhibitors of the RNA-dependent protein kinase.

Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

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526-534

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scholarly article

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10.2337/DB13-1019

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2

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63

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Alessandro Arduini

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2013-10-22T00:00:00Z

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258036749

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