Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis.
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Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite thPresence of a functional but dispensable nuclear export signal in the HTLV-2 Tax protein.Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivoHTLV-1 positive and negative T cells cloned from infected individuals display telomerase and telomere genes deregulation that predominate in activated but untransformed CD4+ T cells.Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression.HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death.Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y.Clonality of HTLV-2 in natural infection.Recombinant human T-cell leukemia virus types 1 and 2 Tax proteins induce high levels of CC-chemokines and downregulate CCR5 in human peripheral blood mononuclear cells.Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells.Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilizationInfection, mutation, and cancer evolution.The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators.Effect of lipopolysaccharide on global gene expression in the immature rat brain.Human T-cell lymphotropic virus type 1 infection of CD34+ hematopoietic progenitor cells induces cell cycle arrest by modulation of p21(cip1/waf1) and survivin.Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line.Functional analysis of human T lymphotropic virus type 2 Tax proteins.
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P2860
Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Human T-cell leukemia virus ty ...... cle progression and apoptosis.
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Human T-cell leukemia virus type 1
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type
label
Human T-cell leukemia virus ty ...... cle progression and apoptosis.
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Human T-cell leukemia virus type 1
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prefLabel
Human T-cell leukemia virus ty ...... cle progression and apoptosis.
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Human T-cell leukemia virus type 1
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P2093
P2860
P1433
P1476
Human T-cell leukemia virus ty ...... cle progression and apoptosis.
@en
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Adam Tripp
Gerold Feuer
Jung-Woo Ma
Michelle Sieburg
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P304
10399-10409
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10.1128/JVI.78.19.10399-10409.2004
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P577
2004-10-01T00:00:00Z