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Circadian systems biology: When time mattersIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesRobustness can evolve gradually in complex regulatory gene networks with varying topologyComputationally derived points of fragility of a human cascade are consistent with current therapeutic strategiesMathematical identification of critical reactions in the interlocked feedback modelThe Per2 negative feedback loop sets the period in the mammalian circadian clock mechanismInvestigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysisBiological switches and clocksComputational modeling and analysis of insulin induced eukaryotic translation initiationBiological robustness: paradigms, mechanisms, and systems principlesInferring Drosophila gap gene regulatory network: a parameter sensitivity and perturbation analysisModule-based analysis of robustness tradeoffs in the heat shock response systemEfficient classification of complete parameter regions based on semidefinite programming.PERIOD-TIMELESS interval timer may require an additional feedback loop.A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trialsCircadian phase resetting via single and multiple control targets.Precise regulation of gene expression dynamics favors complex promoter architectures.Modeling and analysis of the molecular basis of pain in sensory neurons.A method for determining the robustness of bio-molecular oscillator models.'Glocal' robustness analysis and model discrimination for circadian oscillators.Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems.Robustness from flexibility in the fungal circadian clock.Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk.The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.Consistent robustness analysis (CRA) identifies biologically relevant properties of regulatory network modelsDynamically reshaping signaling networks to program cell fate via genetic controllersUnderstanding dynamics using sensitivity analysis: caveat and solutionCircuit topology and the evolution of robustness in two-gene circadian oscillators.Robust entrainment of circadian oscillators requires specific phase response curves.A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems.Efficient characterization of high-dimensional parameter spaces for systems biology.Does the precision of a biological clock depend upon its period? Effects of the duper and tau mutations in Syrian hamsters.Circadian clocks in changing weather and seasons: lessons from the picoalga Ostreococcus tauri.Model-driven designs of an oscillating gene network.Exploring the genetic control of glycolytic oscillations in Saccharomyces cerevisiae.Ensembles of signal transduction models using Pareto Optimal Ensemble Techniques (POETs)Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling.The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose.A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expressionExtension of a genetic network model by iterative experimentation and mathematical analysis.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 August 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Robustness properties of circadian clock architectures.
@en
Robustness properties of circadian clock architectures.
@nl
type
label
Robustness properties of circadian clock architectures.
@en
Robustness properties of circadian clock architectures.
@nl
prefLabel
Robustness properties of circadian clock architectures.
@en
Robustness properties of circadian clock architectures.
@nl
P2860
P356
P1476
Robustness properties of circadian clock architectures.
@en
P2093
Ernst Dieter Gilles
Jörg Stelling
P2860
P304
13210-13215
P356
10.1073/PNAS.0401463101
P407
P577
2004-08-30T00:00:00Z