1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
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The unexpected formation of [M - H]+ species during MALDI and dopant-free APPI MS analysis of novel antineoplastic curcumin analogues.Structure based comprehensive modelling, spatial fingerprints mapping and ADME screening of curcumin analogues as novel ALR2 inhibitors.The gender of cell lines matters when screening for novel anti-cancer drugs.Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agentsSynthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo.E-2-[3-(3,4-dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: a lead antitubercular agent which alters mitochondrial respiration in rat liver.3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: a lead tumor-specific cytotoxin which induces apoptosis and autophagy3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties.A novel class of piperidones exhibit potent, selective and pro-apoptotic anti-leukemia properties.Tumor-selective cytotoxicity of a novel pentadiene analogue on human leukemia/ lymphoma cellsOridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.Synthesis, antitumor activity evaluation of some new N-aroyl-α,β-unsaturated piperidones with fluorescence.Methylenebisphosphonates with dienone pharmacophore: synthesis, structure, antitumor and fluorescent properties.A general HPLC-UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices.Nazarov reaction: current trends and recent advances in the synthesis of natural compounds and their analogs.A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells.Establishment of tandem mass spectrometric fingerprint of novel antineoplastic curcumin analogues using electrospray ionization.
P2860
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P2860
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@en
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@nl
type
label
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@en
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@nl
prefLabel
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@en
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@nl
P2093
P2860
P1476
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
@en
P2093
P2860
P304
P356
10.2174/092986709788682218
P577
2009-01-01T00:00:00Z