Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein. - Wikidata - awgldk - TriplyDB

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.

http://www.wikidata.org/entity/Q37519520

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Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection The role of genetically engineered pigs in xenotransplantation research.Current status of pig heart xenotransplantation.Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs.Xenotransplantation literature update, July-August 2015.The pathobiology of pig-to-primate xenotransplantation: a historical review.Modifying the sugar icing on the transplantation cake.Lung xenotransplantation: a review Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation.Therapeutic regulation of systemic inflammation in xenograft recipients.Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model Recent advances in understanding xenotransplantation: implications for the clinic.Synthetic liver function is detectable in transgenic porcine livers perfused with human blood.Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model.Low anti-pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?Transplantation of hepatocytes from genetically engineered pigs into baboons.N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation.GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.

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Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.

http://www.wikidata.org/entity/Q37519520

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 14 July 2015

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Early graft failure of GalTKO ...... nt pathway-regulatory protein.

@en

Early graft failure of GalTKO ...... nt pathway-regulatory protein.

@nl

type

label

Early graft failure of GalTKO ...... nt pathway-regulatory protein.

@en

Early graft failure of GalTKO ...... nt pathway-regulatory protein.

@nl

prefLabel

Early graft failure of GalTKO ...... nt pathway-regulatory protein.

@en

Early graft failure of GalTKO ...... nt pathway-regulatory protein.

@nl

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Xenotransplantation

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Early graft failure of GalTKO ...... ent pathway-regulatory protein

@en

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Agnes M Azimzadeh

http://www.w3.org/2001/XMLSchema#string

Avneesh K Singh

http://www.w3.org/2001/XMLSchema#string

Chris Avon

http://www.w3.org/2001/XMLSchema#string

David Ayares

http://www.w3.org/2001/XMLSchema#string

David K C Cooper

http://www.w3.org/2001/XMLSchema#string

Evelyn Sievert

http://www.w3.org/2001/XMLSchema#string

Hayato Iwase

http://www.w3.org/2001/XMLSchema#string

Keith A Horvath

http://www.w3.org/2001/XMLSchema#string

Lars Burdorf

http://www.w3.org/2001/XMLSchema#string

Muhammad M Mohiuddin

http://www.w3.org/2001/XMLSchema#string

P2860

alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months

Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity.

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date.

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?

Production of alpha 1,3-galactosyltransferase-deficient pigs.

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation.

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation.

The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients

Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury

B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

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310-316

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scholarly article

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10.1111/XEN.12176

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4

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22

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Mohamed Ezzelarab

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2015-07-14T00:00:00Z

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26174749

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5172381

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