A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia. - Wikidata - awgldk - TriplyDB

A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia.

A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia.

http://www.wikidata.org/entity/Q37525221

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Human Anti-Oxidation Protein A1M--A Potential Kidney Protection Agent in Peptide Receptor Radionuclide Therapy Oxidative Stress in Placenta: Health and Diseases Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders Oxidative stress in preeclampsia and the role of free fetal hemoglobin Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells.Characterization of heme binding to recombinant α1-microglobulin.A1M/α1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.Preeclampsia - will orphan drug status facilitate innovative biological therapies?A1M Ameliorates Preeclampsia-Like Symptoms in Placenta and Kidney Induced by Cell-Free Fetal Hemoglobin in Rabbit.The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators.Biodistribution and pharmacokinetics of recombinant α1-microglobulin and its potential use in radioprotection of kidneys.Biomarker development for presymptomatic molecular diagnosis of preeclampsia: feasible, useful or even unnecessary?The 2015 Pregnancy Summit, London, UK Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.An evaluation of the antioxidant protein α1-microglobulin as a renal tubular cytoprotectant.The Role of Mitochondria, Oxidative Stress, and the Radical-binding Protein A1M in Cultured Porcine Retina.Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia.Decitabine Improves the Clinical Manifestations of Rats With l-NAME-Induced Pre-eclampsia: A Potential Approach to Studying Pre-eclampsia.Podocytes are new cellular targets of haemoglobin-mediated renal damage.Knockdown of pleiotrophin increases the risk of preeclampsia following vitrified-thawed embryo transfer

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A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia.

http://www.wikidata.org/entity/Q37525221

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articolo scientifico

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bilimsel makale

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scientific article published on 28 January 2014

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vetenskaplig artikel

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A1M/α1-microglobulin protects ...... t sheep model of preeclampsia.

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A1M/α1-microglobulin protects ...... t sheep model of preeclampsia.

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JOURNAL.PONE.0086353

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A1M/α1-microglobulin protects ...... t sheep model of preeclampsia.

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Anneli Edström-Hägerwall

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Behnaz Shohani

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Bengt Rippe

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Bo Akerström

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David Ley

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Iréne Larsson

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Josefin Axelsson

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Karel Marsal

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Lena Wester-Rosenlöf

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Madlene Holmqvist

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P2860

Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties

The pregnant sheep as a model for human pregnancy

Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage

Redox properties of the lipocalin alpha1-microglobulin: reduction of cytochrome c, hemoglobin, and free iron.

Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines.

Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes.

Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays

Pathogenesis and genetics of pre-eclampsia.

Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses.

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.

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