High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. - Wikidata - awgldk - TriplyDB

High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.

High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.

http://www.wikidata.org/entity/Q37528345

about

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives.Driving toward targeted therapy for LCH.Update on the biology and treatment options for hairy cell leukemia.Kinetic competition during the transcription cycle results in stochastic RNA processing.Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.Removing a hair of doubt about BRAF targeting.MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking.Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion.Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.Impact of telomere length on survival in classic and variant hairy cell leukemia.Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.The 2016 revision of the World Health Organization classification of lymphoid neoplasms.Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations.Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.Splicing factor mutations and cancer.Splenic marginal-zone lymphoma: ontogeny and genetics.Hairy cell leukemia: a 'hair-raising' update.Novel therapeutic options for relapsed hairy cell leukemia.Cancer genomics: why rare is valuable.Molecular deregulation of signaling in lymphoid tumors.Hairy cell leukemia: update and current therapeutic approach.Whole Exome Profiling of Ocular Surface Squamous Neoplasia.Potential breakthroughs with investigational drugs for hairy cell leukemia.Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations.Hairy cell leukemia: Past, present and future.Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease.Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia.Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets.Lymphoma classification update: B-cell non-Hodgkin lymphomas.How I manage patients with hairy cell leukaemia.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.2016 WHO Classification update-What's new in lymphoid neoplasms.Diagnosis and classification of hematologic malignancies on the basis of genetics.Clinical utility of recently identified diagnostic, prognostic, and predictive molecular biomarkers in mature B-cell neoplasms.Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease.Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma.Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma.

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High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.

http://www.wikidata.org/entity/Q37528345

description

2013 nî lūn-bûn

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2013年學術文章

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2013年學術文章

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2013年學術文章

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name

High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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Nature Genetics

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High prevalence of MAP2K1 muta ...... pressing hairy-cell leukemias.

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Evgeny Arons

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J Keith Killian

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Laura Roth

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Marbin Pineda

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Ogan D Abaan

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Paul S Meltzer

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Robert J Kreitman

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Robert L Walker

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P2860

BRAF mutations in hairy-cell leukemia

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

MEK1 mutations confer resistance to MEK and B-RAF inhibition.

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

ARID1A mutations in cancer: another epigenetic tumor suppressor?

Transformation of mammalian cells by constitutively active MAP kinase kinase

VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy.

Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation

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10.1038/NG.2828

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Joshua J Waterfall

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