Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling - Wikidata - awgldk - TriplyDB

Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

http://www.wikidata.org/entity/Q37537956

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Clarifying lysosomal storage diseases Pathways and mechanisms of endocytic recycling Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells Perfringolysin O Theta Toxin as a Tool to Monitor the Distribution and Inhomogeneity of Cholesterol in Cellular Membranes Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates The endocytic recycling compartment maintains cargo segregation acquired upon exit from the sorting endosome.Endothelial cell migration on fibronectin is regulated by syntaxin 6-mediated alpha5beta1 integrin recycling.Cholesterol level regulates endosome motility via Rab proteins.Glycolipid trafficking in Drosophila undergoes pathway switching in response to aberrant cholesterol levels Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages.Genetic connections between neurological disorders and cholesterol metabolism Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.Inactivation of macrophage Rab7 by Burkholderia cenocepacia.Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.Niemann-Pick type C disease and intracellular cholesterol trafficking.Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.Rab proteins and the compartmentalization of the endosomal system Proteomics of specific treatment-related alterations in Fabry disease: a strategy to identify biological abnormalities.Lysosomal accumulation of SCMAS (subunit c of mitochondrial ATP synthase) in neurons of the mouse model of mucopolysaccharidosis III B.Cholesterol controls lipid endocytosis through Rab11.Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease.Defects in the COG complex and COG-related trafficking regulators affect neuronal Golgi function.ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.Regulation of cholesterol biosynthesis and cancer signaling Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase.Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids.Development of a Rab9 transgenic mouse and its ability to increase the lifespan of a murine model of Niemann-Pick type C disease.Identification of an intracellular site of prion conversion.Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes.Defective cholesterol trafficking in Niemann-Pick C-deficient cells.Cholesterol and cardiac arrhythmias.Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.

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Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

http://www.wikidata.org/entity/Q37537956

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 03 August 2004

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Elevated endosomal cholesterol ...... and perturb membrane recycling

@en

Elevated endosomal cholesterol ...... nd perturb membrane recycling.

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type

label

Elevated endosomal cholesterol ...... and perturb membrane recycling

@en

Elevated endosomal cholesterol ...... nd perturb membrane recycling.

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prefLabel

Elevated endosomal cholesterol ...... and perturb membrane recycling

@en

Elevated endosomal cholesterol ...... nd perturb membrane recycling.

@nl

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MBC.E04-05-0432

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Molecular Biology of the Cell

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Elevated endosomal cholesterol ...... and perturb membrane recycling

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Amit Choudhury

http://www.w3.org/2001/XMLSchema#string

David L Marks

http://www.w3.org/2001/XMLSchema#string

Deepak K Sharma

http://www.w3.org/2001/XMLSchema#string

Richard E Pagano

http://www.w3.org/2001/XMLSchema#string

P2860

Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease

Rab11 regulates recycling through the pericentriolar recycling endosome

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes

Endocytic recycling

Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11

The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

Rab GTPases: specifying and deciphering organelle identity and function

Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol.

The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.

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4500-4511

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scholarly article

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10.1091/MBC.E04-05-0432

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10

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15

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2004-08-03T00:00:00Z

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15292453

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519144

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