Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS. - Wikidata - awgldk - TriplyDB

Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS.

Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS.

http://www.wikidata.org/entity/Q37538542

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Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.Amyotrophic lateral sclerosis-related mutant superoxide dismutase 1 aggregates inhibit 14-3-3-mediated cell survival by sequestration into the JUNQ compartment.

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Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS.

http://www.wikidata.org/entity/Q37538542

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 December 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Motor neurons derived from ALS ...... pathological features of ALS.

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Motor neurons derived from ALS ...... pathological features of ALS.

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type

label

Motor neurons derived from ALS ...... pathological features of ALS.

@en

Motor neurons derived from ALS ...... pathological features of ALS.

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prefLabel

Motor neurons derived from ALS ...... pathological features of ALS.

@en

Motor neurons derived from ALS ...... pathological features of ALS.

@nl

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Experimental and Molecular Medicine

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Motor neurons derived from ALS ...... pathological features of ALS.

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Hang-Soo Park

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Ju-Hwang Park

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Seongman Kang

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Sunghoi Hong

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Misfolded CuZnSOD and amyotrophic lateral sclerosis

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.

Deficits in axonal transport precede ALS symptoms in vivo.

The promise of induced pluripotent stem cells in research and therapy

Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons.

Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice

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e276

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scholarly article

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10.1038/EMM.2016.113

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12

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48

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2016-12-09T00:00:00Z

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1033228801

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27932790

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amyotrophic lateral sclerosis

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5192071

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