Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
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Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell LineOxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer CellsSialylation of outer membrane porin protein D: a mechanistic basis of antibiotic uptake in Pseudomonas aeruginosa.Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis.Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia.miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway.Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme.Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor.Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivoHeat-shock protein 90 (Hsp90) as anticancer target for drug discovery: an ample computational perspective.Carbazole alkaloids from Murraya koenigii trigger apoptosis and autophagic flux inhibition in human oral squamous cell carcinoma cells.Targeting reactive oxygen species in development and progression of pancreatic cancer.Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma.mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation.A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cells.Therapeutic potency of heat-shock protein-90 pharmacological inhibitors in the treatment of gastrointestinal cancer, current status and perspectives.Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells.Mahanine drives pancreatic adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation process and Ca2+-signaling.Autophagy-independent induction of LC3B through oxidative stress reveals its non-canonical role in anoikis of ovarian cancer cells
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P2860
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 July 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Oxidative inhibition of Hsp90 ...... arcinoma in vitro and in vivo.
@en
Oxidative inhibition of Hsp90 ...... arcinoma in vitro and in vivo.
@nl
type
label
Oxidative inhibition of Hsp90 ...... arcinoma in vitro and in vivo.
@en
Oxidative inhibition of Hsp90 ...... arcinoma in vitro and in vivo.
@nl
prefLabel
Oxidative inhibition of Hsp90 ...... arcinoma in vitro and in vivo.
@en
Oxidative inhibition of Hsp90 ...... arcinoma in vitro and in vivo.
@nl
P2093
P2860
P356
P1476
Oxidative inhibition of Hsp90 ...... carcinoma in vitro and in vivo
@en
P2093
Bikas Chandra Pal
Chhabinath Mandal
Chitra Mandal
Devawati Dutta
Jinping Li
Kaushik Bhattacharya
Kaustubh Datta
Sayantani Sarkar
P2860
P304
P356
10.1002/IJC.27687
P577
2012-07-09T00:00:00Z