GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
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Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitorsGadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expressionActivation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domainGadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress.Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.Gadd45a is an RNA binding protein and is localized in nuclear speckles.Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course.Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.Gadd45b and Gadd45g are important for anti-tumor immune responsesSelective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activityDifferential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C.Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient miceObesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease.The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells.SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells.TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma.Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication.Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.GADD45 proteins: roles in cellular senescence and tumor development.GADD45γ regulates TNF-α and IL-6 synthesis in THP-1 cells.MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.MEKK4 sequesters RIP2 to dictate NOD2 signal specificitySuppression of Gadd45 alleviates the G2/M blockage and the enhanced phosphorylation of p53 and p38 in zinc supplemented normal human bronchial epithelial cells.Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells.Molecular Characterization, Polymorphism, and Association of Porcine GADD45G Gene.p38α regulates cytokine-induced IFNγ secretion via the Mnk1/eIF4E pathway in Th1 cells.Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3
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P2860
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 March 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
GADD45beta/GADD45gamma and MEK ...... FNgamma production in T cells.
@en
GADD45beta/GADD45gamma and MEK ...... FNgamma production in T cells.
@nl
type
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GADD45beta/GADD45gamma and MEK ...... FNgamma production in T cells.
@en
GADD45beta/GADD45gamma and MEK ...... FNgamma production in T cells.
@nl
prefLabel
GADD45beta/GADD45gamma and MEK ...... FNgamma production in T cells.
@en
GADD45beta/GADD45gamma and MEK ...... FNgamma production in T cells.
@nl
P2093
P2860
P356
P1433
P1476
GADD45beta/GADD45gamma and MEK ...... IFNgamma production in T cells
@en
P2093
Binfeng Lu
Mutsuhiro Takekawa
Richard A Flavell
Roger J Davis
P2860
P304
P356
10.1038/SJ.EMBOJ.7600173
P407
P50
P577
2004-03-25T00:00:00Z